TY - JOUR ID - 170300 TI - Quantitative Electroencephalography Findings in Treatment-resistant and Responsive Patients with Idiopathic Generalized Tonic-Clonic Epilepsy JO - Neurology Letters JA - NL LA - en SN - AU - Shaafi, Sheida AU - Nasibi, Seyede Maryam AU - Chalabianloo, Gholamreza AU - Nejadghaderi, Seyed Aria AD - Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran AD - Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran AD - Department of Psychology, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran AD - School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Y1 - 2023 PY - 2023 VL - 2 IS - 1 SP - 6 EP - 12 KW - Quantitative Electroencephalography KW - QEEG KW - Idiopathic generalized epilepsy KW - Tonic-clonic seizure KW - Anti-epileptic drug resistance DO - 10.52547/nl.2.1.6 N2 - Background: With roughly 50 million people affected in the world, epilepsy is a particularly important disorder of the brain commonly diagnosed based on findings of quantitative electroencephalography (QEEG). The present investigation was aimed to evaluate differences in QEEG readings of drug-resistant and drug-responsive patients with idiopathic generalized epilepsy (IGE) with tonic-clonic seizures in a northwestern Iranian population.Methods: A total of 60 participants, consisting of 30 drug-resistant and 30 drug-responsive patients with IGE, were enrolled. Data, including demographic information and Z-transformed absolute power values of QEEG in anterior, central, and posterior alpha, beta, delta, and theta bands were collected. The analysis was conducted using IBM SPSS and a p-value<0.05 was considered statistically significant.Results: Of the 60 participants with a mean age of 31.55 ± 10.48, 41 (68.3%) were female and 19 (31.7%) were male. Statistically significant differences were observed in anterior alpha, beta and theta bands, central alpha, beta, delta and theta bands, and posterior beta, delta and theta bands between the two groups, with the absolute power Z-scores of the drug-resistant groups being significantly higher than the other (P-values<0.05). Abnormal EEGs were recorded for 16 (53.3%) and 5 (23.8%) patients from the drug-resistant and drug-response groups, respectively, indicating a significant difference (P-value=0.006). Female patients were more likely to have the drug-resistant disease than male participants (P-value=0.003).Conclusions: QEEGs with normal readings indicate a more favorable prognosis, compared with those containing abnormal findings. UR - https://www.neurologyletters.com/article_170300.html L1 - https://www.neurologyletters.com/article_170300_eebacbd0bef6c3da959b8210eb64cdec.pdf ER -