Evaluation of allergy and respiratory allergen sensitization profile in patients with Multiple Sclerosis (PP-08)

Document Type : Poster Presentation

Authors
Sina Nouri
Arash Aminpour
Hamidreza Khalkhali
Arash Mosarreaii Aghdam
Sadegh Feizollahzadeh
.
Abstract
Background: Multiple Sclerosis (MS) concomitancy with other immune-related disorders with contradictory pathogenesis like allergies may affect course and severity of each other.
Objective: To further elucidate the interplay between MS and allergy, we evaluated the allergy prevalence, the allergen patterns, and the effect of MS medications on allergy in MS patients.
Methods: This study was conducted on patients who were members of the MS Association of Urmia, Iran. Demographic data was obtained through interviews and serum IgE titer and respiratory allergen profile was determined by ELISA and immunoblot, respectively.
Results: A total of 124 MS patients participated in this study. 14.5% of patients had high serum IgE and 20% had allergy symptoms. The most common allergens were pollinating grass, among them Meadow Foxtail was associated with higher titers of specific IgE. IgE titer did not show any significant difference in patients receiving different MS drugs (p-value > .05), however, the IgE titer was the highest in patients receiving glatiramer acetate and the lowest in patients receiving dimethyl fumarate.
Conclusion: Allergy is common in MS patients and is less severe under the influence of treatment or paradoxical pathogenesis. It seems that allergic MS patients tend to show a certain pattern of allergens.

Keywords

  • Receive Date 05 December 2024
  • Publish Date 01 October 2024