Acute disseminated encephalomyelitis following vaccination against SARS-cov-2: a case report (PP-04)

Document Type : Poster Presentation




Introduction: ADEM an inflammatory demyelinating discase of the central nervous system that is usually considered a monopnasic disease. Post-vaccination ADEM has been associated with severa vaccines. however there is scarce information related to SARS-CoV-2 vac-cines. We report the case of a 26-year-old female who suffered from ADEM four weeks after Gam-COVID-Vac administration.
Result: A 26-vear-old female was admitted affer 10 davs of temporal spatial disorientation, inappropriate behavior and headache. She reported no upper respiratory infection or diarrhea and she has no significant medical history. Four weeks prior admission she received a first dose of Gam-COVID-vac vaccine (humai adcnovirus viral vector). Neurological examination showed failure cognitive function in attention, deferred memory, orientation visuospatial and language. Montreal Cognitive Assessmen (MoCA) 12/30. Also right upper limb weakness and gait ataxia was noted. Her brain MRI showed widespread abnormal signals on FLAIR images with ring enhancement pattern. Analysis of cerebrospinal fluid was normal and oligo clonal bands were positive. ADEM was suspected and she was treated wit intravenous Methylprednisolone with partial recovery. MoCA at 30 days was 24/30.
Conclusion: our patient met the ADEM diagnostic criteria diagnosis were excluded .although a plausible relationship was not demonstrated. The possibility of association with vaccine is suspected


  • Receive Date: 17 December 2023
  • Accept Date: 17 December 2023